.: Sarcomatoid Mesothelioma: A Deadly Curse Of Asbestos
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Sarcomatoid Mesothelioma is a quite uncommon type of cancer caused due to asbestos exposure. While it is difficult to diagnose Sarcomatoid Mesothelioma, it hardly responds to any type of therapy. This is the most serious of all asbestos-related diseases. The possibility of finding this type of cancer is on the lips and the larynx. However, in certain cases it may affect the oral cavity as well. Like all other forms of mesothelioma cancers, this cancer is a fatal disease and hardly responds to any method of treatment. Even though radiation therapy is recommended for the treatment of these cancerous tumors, but some of them may not be radiosensitive and may defy radiation for treatment.
Diagnosis of Sarcomatoid Mesothelioma:
The differentiation of sarcomatoid mesothelioma from other cell tumors by light microscopy is quite difficult. The role of immunohistochemistry is also not well defined in its diagnosis. Since sarcomatoid mesothelioma is not always cytokeratin-negative, the distinction between it and sarcoma is not always possible. In this context, the doctors undertook a study to investigate the utility of diagnostic immunohistochemistry for distinguishing sarcomatoid mesothelioma from its histological mimics, high-grade sarcoma and pulmonary sarcomatoid carcinoma.
For its study, the researchers stained the mesotheliomas with sarcomatoid components. They assessed the intensity and distribution of staining with the help of a semi quantitative scale. Only tumors with unequivocal staining were considered positive for tabulation. Then they compared the immunophenotypic profiles of these tumors with 24 high-grade sarcomas. The sarcomatoid carcinomas were also stained for thyroid transcription factor-1 (TTF-1).
The study showed that Cytokeratin 5/6 stained most of the epithelioids but the sarcomatoids were rarely stained. On the other hand, Calretinin and thrombomodulin each stained 70% of sarcomatoid. All 10 sarcomatoids were negative for TTF-1. This led to the conclusion that a wide immunophenotypic overlap exists among different sarcomatoids. Cytokeratin and calretinin have the most value in differentiating different sarcomatoids. Clinicopathological data, especially information about the gross appearance of the tumor is quite important for sarcomatoid tumors. Thus, it should be noted and carefully correlated with microscopic and immunohistochemical findings.
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Kirsten Hawkins is a asbestos and mesothelioma specialist from Nashville, TN. Visit www.asbestosblog.org/ for information on asbestos reform, mesothelioma lawsuit news, and more.
.: New Mesothelioma Articles
1). Diffuse Malignant Pleural Mesothelioma
Diffuse malignant pleural mesothelioma, or DMM, is a rare but highly aggressive type of cancer. It occurs in the thin layer of tissue, the pleura, lining the chest cavity and lungs. Once diagnosed with DMM, most patients do not survive beyond one year. This cancer is more common in men than in women, and in older people.
Most people with DMM have a history of exposure to asbestos; however, if they are not aware that such exposure occurred, they may be unaware that they are at risk.
2). Pericardial Mesothelioma: Quick Facts
What is pericardial mesothelioma ?
It is a cancer caused by the inhalation of asbestos dust, and is the most rare of mesothelioma cancers. It accounts for about 5% of all cases.
Its period of latency (time it takes for the symptoms to show) is approximately 30-50 years. Symptoms are similar to other diseases such as pneumonia whilst in the early stages.
3). What is pericardial mesothelioma ?
Mesothelioma is a cancer of the epithelium that lines the lungs, the abdomen, or the heart. Pericardial Mesothelioma is the cancer of the lining of the heart, known as the pericardium, hence the name pericardial mesothelioma.
This rare form of mesothelioma accounts for small percentage of all cases, roughly 5%. The pericardium has an extrememly important role as it protects the heart from any damage.
4). How do you treat pericardial mesothelioma ?
Of all the cancers caused by asbestos dust (mesothelioma), pericardial mesothelioma is the most rare, accounting for a fraction of all cases (5%). It is a cancer that grows on the pericardium (the lining of the heart). This is a delicate 'film', and any infection on the pericardium can have deadly consequences.
Once an individual has been diagnosed with pericardial mesothelioma they are offered three different treatment options.
5). Mesothelioma Lawsuits
Mesothelioma Lawsuits are not unique: As long as there have been environmental factors with impact on our health as well as a legislative system, people have filed lawsuits if the impact has been of a negative kind. Mesothelioma is a cancer primarily focused on the cells surrounding the lungs. This cancer has been associated exclusively with the exposure to asbestos which was commonly used in industrial and residential uses up until the late 1970's.
6). The Facts about Mesothelioma Cancer
What is Mesothelioma Cancer?
Mesothelioma cancer is an extremely rare cancer form that is only found in the mesothelium. This form of malignancy generally affects those people who have been exposed to a situation where asbestos is present, typically those who have worked in buildings where it was used as a fire retardant..
What happens when a person has Mesothelioma Cancer?
This type of cancer directly affects the mesothelium and causes abnormal cells.
7). What Are The Risk Factors For Malignant Mesothelioma?
A risk factor is anything that increases your chance of getting a disease such as cancer. Different cancers have different risk factors. For example, exposing skin to strong sunlight is a risk factor for skin cancer. Smoking is a risk factor for cancers of the lung, mouth, larynx, bladder, kidney, and several other organs. Individuals exposed to asbestos should be encouraged to avoid tobacco exposure because together the risk for lung cancer is significantly higher than from smoking without a history of asbestos exposure.
.: Top Mesothelioma Articles
1). Mesothelioma
Tragically the word mesothelioma is becoming more and more well known, the mere mention of it striking fear into all of us for we know that it is associated with death. Asbestos is the reaper, mesothelioma its hand maiden.
Asbestos, the wonder product of the fifties is now recognized as an enemy of the twentieth century. A ruthless enemy which will kill more people than the war.
2). Mesothelioma Sarcoma
What Is Mesothelioma Sarcoma?
Between the two forms of tumors of the mesothelioma, which are either benign (non-cancerous) or malignant (cancerous), the latter is more common and dangerous, popularly known as mesothelioma. Mesothelioma is characterized by its dangerous potential to spread to other parts of the body.
Types of Mesothelioma
There are three different types of Mesothelioma:
1) Ephitheliod: It affects the membranous tissue covering the internal organs and surfaces of the body.
3). Peritoneal Mesothelioma – The cancer of abdominal lining
One of the fatal types of mesothelioma is Peritoneal Mesothelioma in which the cancerous cells attack the lining of the abdomen called Peritoneum. Peritoneum is the thin membrane, which shields various organs of the abdomen and also provides a lubricating fluid to enable the organs to move and work properly. Peritoneal Mesothelioma, which affects this lining, is yet now a relatively rare disease that accounts for about 1/5 of all mesotheliomas.
4). Mesothelioma Is An Incurable Cancer That Makes Lawyers Rich
Mesothelioma develops in approximately 3,000 United States citizens every year. Most of those diagnosed have a history of occupational exposure to asbestos, though a few have environmental or household contact.
5). Mesothelioma Symptoms
The term “Mesothelioma” in medical terms is defined as form of cancer that proliferates at a very fast rate after it has been diagnosed, which affects the mesothelial cells in the body. After detailed study of this disease by several scientists all over the world, it has been concluded that in most of the cases the reason is the direct contact with loose asbestos particles. This disease is generally known to be derived from an abnormality that arises from inhaling the loose asbestos particles
6). How Did I Get Cancer? - Asbestos!
Exposure to asbestos usually occurs by breathing contaminated air in workplaces that make or use asbestos. Asbestos is also found in the air of buildings containing asbestos that are being torn down or renovated. Asbestos exposure can cause serious lung problems and cancer. This substance has been found in at least 83 of the 1,585 National Priorities List sites identified by the Environmental Protection Agency (EPA).
If inhaled by humans, asbestos fibres can cause asbestos...
7). What are the main symptoms of Mesothelioma?
The term “Mesothelioma” in medical terms is defined as form of cancer that
proliferates at a very fast rate after it has been diagnosed, which affects the mesothelial cells in the body. After detailed study of this disease by several scientists all over the world, it has been concluded that in most of the cases the reason is the direct contact with loose asbestos particles.